Factor V Leiden > Factor V Leiden occurs as a result of a single point mutation in the factor V gene at the cleavage site (position 506) where protein C acts. Diagnosis The diagnosis of Factor V Leiden is usually made by a genetic, or DNA, test done on a blood sample. Management Factor V Leiden (FVL) mutation . This 267 base pair gene segment contains nucleotide 1691, which is where the most common mutation occurs. FVL is the most common cause of activated protein C resistance … Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. Four meta-analyses assessed the association between fetal loss and maternal factor V Leiden. A study of >5,000 asymptomatic gravidas found no association between abruptio placenta and factor V Leiden mutation I believe my sister takes a blood thinner, but we boys take low-dose aspirin. Karadağ C(1), Akar B(2), Gönenç G(1), Aslancan R(3), Yılmaz N(4), Çalışkan E(1). What to Include in the Screening Panel. The patient is healthy, has no chronic medical conditions, and takes no long-term medications. Pregnancy. Check the latest reports from 992 Factor v leiden mutation patients, or browse all conditions. Re : Factor V Leiden, heparin, and aspirin Post by [email protected] » Wed Jan 17, 2007 01:23 am Given a patient with heterozygosity for Factor V Leiden, I want to know whether she has any other thrombophilic risk involving a prothrombin gene mutation especially (or any other) and whether or not she has had a prior thromboembolic event. Low dose aspirin during pregnancy stef__0. Factor V Leiden results from a single point mutation in the factor V gene that causes a poor anticoagulant response to activated protein C. The inheritance of the defective gene may be expressed as either homozygous or heterozygous factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. factor v leiden can't be cured, because it's a problem with a gene. Fast Track. Most women with factor V Leiden have normal pregnancies and only require close follow-up during pregnancy. A recent prospective cohort study and subsequent updated meta-analysis has now demonstrated that carriership for either factor V Leiden or prothrombin gene mutation is not associated with adverse pregnancy outcomes apart from a weak association between factor V Leiden and pregnancy loss . I am confident in my ob doc. Hi, I've had 2 previous miscarriages (both early) and they found that I have got heterozygous factor V leiden recently. Both men and women can have factor V Leiden. Factor V Leiden (FVL) results from a point mutation in the F5 gene, which encodes the factor V protein in the coagulation cascade.