When did the Inca Empire end? First, European diseases had spread throughout the region of the Inca Empire in the years before Pizarro first encountered the civilization. The Battle of Cajamarca was the beginning of the end of the Inca Empire. With the arrival from Spain in 1532 of Francisco Pizarro and his entourage of mercenaries or "conquistadors," the Inca empire was seriously threatened for the first time. 800 AD - The Nazca and Moche civilizations come to an end. 800 AD - The Nazca and Moche civilizations come to an end. As the last emperor of the largest empire in pre-Columbian Empire, Atahualpa was an immensely powerful leader. The Inca Empire arose from the highlands of Peru sometime in early 13th century. The Inca Empire (or Inka Empire) was the largest empire in pre-Columbian America. Inca leaders kept records of what each ayllu in the empire produced, but did not tax them on their production. 1200 AD - The Chimu build their capital city Chan Chan. The conquest of the Inca Empire unfolded as a series of major events. The Inca Empire was the largest prehispanic society of South America when it was 'discovered' by the Spanish conquistadors led by Francisco Pizarro in the 16th century AD. The soldiers and people of the Inca Empire did not meekly turn over their homeland to the hated invaders. Spain gained riches from the Inca gold and silver. Inca, South American Indians who, at the time of the Spanish conquest in 1532, ruled an empire that extended along the Pacific coast and Andean highlands from the northern border of modern Ecuador to the Maule River in central Chile. 1200 AD to 1400 AD - The Inca live in and around the city-state of Cuzco. In 1572 the last Inca stronghold was discovered, and the last ruler, Túpac Amaru, Manco's son, was captured and executed, bringing the Inca empire to an end. Inca Empire 1200 AD - The Inca tribe, led by Manco Capac, founded the city of Cuzco in the Cuzco Valley region. 1532. Between 1519 to 1533, the white Christian man discovered and destroyed in a most foul manner, 3 glorious civilizations - the Aztecs of Mexico, Maya of Yuacatan and Guatemala and Inca of Peru. The beginning of the end With the arrival from Spain in 1532 of Francisco Pizarro and his entourage of mercenaries or "conquistadors," the Inca empire … At its height, the Inca empire controlled all of the western part of the … One of the world's oldest civilizations, the Inca Empire was a pre-Columbian empire located in the western part of South America.By 1527, the Inca Empire spanned an area of about 770,000 sq mi (2,000,000 km 2), making it one of the largest empires in the world during the 16th century. Major Inca generals such as Quisquis and Rumiñahui fought pitched battles against the Spanish and their native allies, notably at the 1534 Battle of Teocajas. The Inca Empire was the largest prehispanic society of South America when it was 'discovered' by the Spanish conquistadors led by Francisco Pizarro in the 16th century AD. After the Spanish conquest. At its height, the Inca empire controlled all of the western part of the South American continent between Ecuador and Chile. Although the Spanish laid claim to the fall of the Incas, it was widely considered that the empire was already in …